Targeting integrase enzyme: a therapeutic approach to combat HIV resistance

D Komal, J Khushboo, S Aaftaab… - Mini Reviews in …, 2020 - ingentaconnect.com
5-amino substituted 4-fluorobenzyl-8-hydroxy-(1,6)naphthyridine-7-carboxamide as HIV IN
inhibitors… In this pursuit, Zhao and co-workers designed and synthesized bicyclic hydroxyl-1-H

Naphthyridines with antiviral activity-a review

IP Singh, S Kumar, S Gupta - Medicinal Chemistry, 2017 - ingentaconnect.com
… Compound 22 was a potent inhibitor of HIV-1 integrase and a highly homologous enzyme …
series of 5-pyrrolidinone derivatives (51-56) of 8hydroxy[1,6]-naphthyridine-7-carboxamide (…

Inhibiting HCMV pUL89-C Endonuclease with Metal-Binding Compounds: Miniperspective

AD Jagtap, RJ Geraghty, Z Wang - Journal of medicinal chemistry, 2023 - ACS Publications
… at the 5-position of the core were important for HIV-1 inhibition in cells. To gain better
understanding on pUL89-C inhibition, the 8-hydroxy-1,6-naphthyridine-7-carboxamide … …